The correlation of endothelin-1 and dyslipidemia in migraineurs

Abstract

Objective To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them. Methods The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detected by automatic biochemical detector and serum ET-1 level of two groups was measured by radioimmunoassay method. Results Compared with healthy control group, the levels of total cholesterol (TC), trighyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ET-1 in migraine group, especially patients with dyslipidemia, were significantly higher (P < 0.05, for all), while the difference of high-density lipoprotein cholesterol (HDL-C) level had no statistical significance (P > 0.05). Serum ET-1 content in migraine group was positively correlated with the levels of TC (rs = 0.208, P = 0.043), TG (rs = 0.331, P = 0.001), LDL-C (rs = 0.217, P = 0.035), but was not correlated with HDL-C level (rs = -0.099, P = 0.341). Conclusion The changes of serum lipid and ET-1 level play an important role in the process of migraine attacks. Serum ET-1 has positive correlation with TG, TC, LDL-C levels, suggesting the correlation of serum lipid and ET-1 in acute period migraineurs and effective control for serum lipid has important significance for the prevention of migraine and cardiovascular diseases.