Clinical study on the prevention of spontaneous intracerebral hemorrhage of lower extremity deep venous thrombosis by neuromuscular electrical stimulation

Abstract

Objective To investigate the effectiveness and safety of neuromuscular electrical stimulation (NMES) in the prevention of spontaneous intracranial hemorrhage (sICH) in lower extremity deep venous thrombosis (DVT). Methods A total of 76 patients with sICH from January 2019 to January 2020 were included. They were randomized to receive basic prevention methods of venous thrombosis (control group,n=38)and treatment with NMES(NMES group,n=38). The incidence of DVT of lower extremity, plasma D⁃dimer levels and adverse event rates were compared between 2 groups on 7 d of admission. The prognosis of neurological function was evaluated with Glasgow Outcome Scale (GOS) 3 months after onset. Results No pulmonary thromboembolism occurred in 2 groups within 7 d after admission, and the incidence of lower extremity DVT in the NMES group was lower than that in the control group [18.42% (7/ 38) vs. 44.74% (17/38); χ2=6.090, P=0.014]. Three days after admission, the plasma D⁃dimer level in the 2 groups was higher than that on the day of admission (P=0.000), while plasma D⁃dimer level in the NMES group was also higher than that in the control group (P=0.000). No adverse events such as skin damage or inflammation occurred in the NMES group. The prognosis of the NMES group was better than that of the control group 3 months after onset [GOS grade (3.42±1.28) vs. (2.55±1.13); t=3.124, P=0.000]. Conclusions NMES can help to prevent DVT of lower extremity in patients with sICH.

DOI：10.3969/j.issn.1672⁃6731.2020.08.009