Effect of internal carotid artery stenting on mild cognitive impairment of patients with asymptomatic internal carotid artery stenosis

Abstract

Objective To explore effect of internal carotid artery (ICA) stenting on mild cognitive impairment (MCI) of patients with asymptomatic ICA stenosis. Methods Fifty-four patients with severe ICA stenosis (stenosis rate ≥ 70%) from October 2016 to September 2018 were studied. Cognitive function was examined in 54 patients with asymptomatic ICA stenosis 24 h before operation and 1 month, 3 months, 6 months after operation. Cognitive function was assessed with the Mini-Mental State Examination (MMSE), Trail Making Test (TMT) and Stroop Color-Word Test (SCWT). Results There were statistical differences in MMSE (P = 0.000), time of TMT-A and TMT-B (P = 0.000, 0.000), time of SCWT-A, SCWT-B and SCWT-C (P = 0.000, 0.036, 0.000), and correct number of SCWT-A (P = 0.005) before and after ICA stenting. MMSE, time of TMT-A, TMT-B and SCWT-A at 3 and 6 months after stenting were shorter than before and one month after stenting (P < 0.05, for all), while time of SCWT-C was shorter than before stenting (P < 0.05, for all). Time of SCWT-B at 6 months after stenting was shorter than before stenting (P < 0.05, for all). Correct number of SCWT-A at 6 months after stenting was higher than before and 3 months after stenting (P < 0.05, for all), which at 3 monthes after stenting was lower than one month after stenting (P < 0.05, for all). Conclusions ICA stenting can help to improve the MCI patients with asymptomatic ICA stenosis.

DOI:10.3969/j.issn.1672-6731.2019.10.007