A 100-year history of Guillain-Barré syndrome

Abstract

Guillain-Barré syndrome (GBS) is an autoimmune disease mainly involving the peripheral nervous system. Since the description of its core clinical features by Guillain and Barré 100 years ago, the understanding of pathogenesis of GBS was greatly improved with recognition of its clinical diversity, and studies on its pathology, immunology, electrophysiology and animal models. This paper reviews a 100-year history of research progress in its clinical manifestation, pathophysiology and pathogenesis, diagnostic criteria, treatment and outcomes, and the relationship with vaccination in chronological order, to give a comprehensive presentation on the relationship between research progress and the development of clinical practice in GBS.

DOI: 10.3969/j.issn.1672-6731.2016.09.002